Pet Recall Facts

Ingredients / Esafoxolaner

Esafoxolaner: FDA adverse event reports for pets

Reports received through June 26, 2026. Data and limitations.

3,332Total reports
15Dog reports
3,138Cat reports

FDA-approved products with this ingredient (Green Book)

All approved products with this ingredient, for any species.

Brand names come only from the Green Book. Brand names in FDA's public report data are masked, so counts cannot be attributed to any brand. Ingredient names in the reports are written many ways; we group them under one ingredient name and count each report once per ingredient (method).

Reports by year received

2023604
20241,219
20251,075
2026434

Species named in reports

Cat3,138
Not given132
Human46
Dog15
Bobcat1

Signs reported after Esafoxolaner

Lethargy (see also Central nervous system depression in Neurological)511
Vomiting412
Hypersalivation289
Application site hair loss288
Foaming at the mouth254
Drooling214
Not eating208
Lack of efficacy (ectoparasite) - flea203
Ataxia194
Accidental exposure193
Lack of efficacy (endoparasite) - roundworm NOS172
Lack of efficacy (endoparasite) - tapeworm163
Death by euthanasia126
Hiding125
Behavioural disorder NOS118
Seizure NOS117
Licking at application site109
Diarrhoea109
Tremor109
Death104
Dilated pupils94
Anorexia93
Incorrect route of drug administration85
Hyperglycaemia81
Vocalisation80

Breeds named in reports

Domestic Shorthair1,947
Cat (unknown)432
Domestic Longhair230
Domestic Mediumhair198
Siamese63
Maine Coon54
Ragdoll32
Mixed (Cat)31
Crossbred Feline/cat26
Russian18
Persian18
American Shorthair18
Bengal17
Himalayan10
Manx7

Reported outcomes

Outcome Unknown1,815
Recovered/Normal906
Ongoing246
Euthanized123
Died119
Recovered with Sequela5

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