Ingredients / Medetomidine
Medetomidine: FDA adverse event reports for pets Reports received through June 26, 2026. Data and limitations .
3,197 Total reports
2,645 Dog reports
468 Cat reports
These are reports sent to FDA. A report does not prove that the product caused the problem: the animal may have had another illness, been given other products, or the event may have happened by chance. Counts depend on how widely a product is used and how often people report, so they cannot be used to compare products or estimate risk. Talk to your veterinarian before starting, stopping or changing any medication.
“An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another...”
FDA, openFDA FDA-approved products with this ingredient (Green Book) All approved products with this ingredient, for any species.
Domitor® (Orion Corp.) Placadine™ (Modern Veterinary Therapeutics, LLC) Zenalpha® (Dechra Veterinary Products LLC) Brand names come only from the Green Book. Brand names in FDA's public report data are masked, so counts cannot be attributed to any brand. Ingredient names in the reports are written many ways; we group them under one ingredient name and count each report once per ingredient (method ).
Reports by year received 1996 19
1997 338
1998 297
1999 215
2000 229
2001 165
2002 148
2003 110
2004 182
2005 184
2006 211
2007 174
2008 197
2009 38
2010 8
2011 2
2012 3
2013 6
2014 4
2015 3
2016 3
2017 2
2018 3
2019 3
2020 1
2021 3
2022 85
2023 215
2024 161
2025 133
2026 54
Species named in reports Dog 2,645
Cat 468
Human 23
Not given 22
Other 11
Monkey 5
Rabbit 4
Rat 3
Signs reported after Medetomidine INEFFECTIVE, SEDATION 687
Death 491
Lack of efficacy - NOS 312
Sedation prolonged 246
Vomiting 217
Bradycardia 197
Cardiac arrest 189
Apnoea 161
Depression 147
Convulsion 142
Anorexia 137
Labelled drug-drug interaction medication error 122
Diarrhoea 115
Hypersalivation 92
Fever 91
Lung oedema 86
Tachycardia 84
Death by euthanasia 83
Cyanosis 81
Elevated alanine aminotransferase (ALT) 81
Dyspnoea 80
Ataxia 77
Vocalisation 73
Elevated serum alkaline phosphatase (SAP) 70
Recovery prolonged 70
Breeds named in reports Dog (unknown) 498
Crossbred Canine/dog 347
Domestic (unspecified) 270
Retriever - Labrador 244
Rottweiler 134
Shepherd Dog - German 132
Cat (unknown) 97
Retriever - Golden 96
Mixed (Dog) 91
Chow Chow 61
Poodle (unspecified) 52
Boxer (German Boxer) 50
Spaniel - Cocker American 46
Chihuahua 45
Shih Tzu 38
Reported outcomes Died 563
Recovered/Normal 509
Outcome Unknown 110
Euthanized 33
Ongoing 32
Recovered with Sequela 1
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