Pet Recall Facts

Ingredients / Polysulfated Glycosaminoglycan

Polysulfated Glycosaminoglycan: FDA adverse event reports for pets

Reports received through June 26, 2026. Data and limitations.

7,988Total reports
5,813Dog reports
482Cat reports

FDA-approved products with this ingredient (Green Book)

All approved products with this ingredient, for any species.

Brand names come only from the Green Book. Brand names in FDA's public report data are masked, so counts cannot be attributed to any brand. Ingredient names in the reports are written many ways; we group them under one ingredient name and count each report once per ingredient (method).

Reports by year received

19877
19884
19891
19906
19916
19927
19932
19947
19955
19969
19978
199820
199928
200011
200116
200222
20039
200437
200559
2006110
2007182
2008180
2009224
2010270
2011248
2012349
2013297
2014302
2015335
2016667
2017755
2018453
2019411
2020369
2021352
2022464
2023481
2024612
2025553
2026110

Species named in reports

Dog5,813
Not given1,073
Horse558
Cat482
Human35
Other9
Other Birds7
Rabbit4

Signs reported after Polysulfated Glycosaminoglycan

Vomiting1,541
Diarrhoea1,052
Lethargy (see also Central nervous system depression in Neurological)896
Lack of efficacy - NOS621
Product Defect, General606
Anorexia552
Death by euthanasia455
Not eating424
Elevated alanine aminotransferase (ALT)346
Other abnormal test result NOS328
Depression324
Weight loss305
Color, Abnormal272
Elevated serum alkaline phosphatase (SAP)253
Death241
Decreased appetite238
Elevated blood urea nitrogen (BUN)224
Bloody diarrhoea224
Ataxia201
Anaemia NOS199
Injection site pain194
Behavioural disorder NOS194
Fever192
Elevated creatinine192
Pain NOS189

Breeds named in reports

Retriever - Labrador1,092
Dog (unknown)954
Shepherd Dog - German448
Retriever - Golden373
Crossbred Canine/dog265
Domestic Shorthair228
Boxer (German Boxer)153
Rottweiler145
Horse (unknown)136
Shepherd Dog - Australian127
Dog (other)126
Quarter Horse123
Collie - Border116
Chihuahua111
Siberian Husky99

Reported outcomes

Outcome Unknown1,882
Recovered/Normal1,739
Ongoing1,270
Euthanized381
Died353
Recovered with Sequela46

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