FDA-approved products with this ingredient (Green Book)
No matching Green Book entry is supplied in this dataset. This alone does not establish regulatory status.
EPA-registered pesticide. Flea and tick products with this ingredient, such as many collars, spot-ons and shampoos, are registered by the U.S. Environmental Protection Agency (EPA), not approved by FDA, so they have no FDA Green Book record. Pet owners still send reports about them to FDA, and those reports are counted here. Questions about these products: National Pesticide Information Center.
Brand names come only from the Green Book. Brand names in FDA's public report data are masked, so counts cannot be attributed to any brand. Ingredient names in the reports are written many ways; we group them under one ingredient name and count each report once per ingredient (method).
Reports by year received
20116
201295
2013146
2014128
2015130
2016131
2017257
2018207
2019191
2020168
2021161
2022155
2023124
2024139
2025101
202635
Species named in reports
Dog1,645
Cat519
Human6
Not given3
Rabbit1
Signs reported after Pyriproxyfen
Lack of efficacy (ectoparasite) - flea399
Lethargy (see also Central nervous system depression in Neurological)314